Biomolecular Crystallography: Principles, Practice, and Application to Structural Biology [Hardcover] Author: Bernhard Rupp | Language: English | ISBN:
0815340818 | Format: PDF, EPUB
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Synthesizing over thirty years of advances into a comprehensive textbook, Biomolecular Crystallography describes the fundamentals, practices, and applications of protein crystallography. Deftly illustrated in full-color by the author, the text describes mathematical and physical concepts in accessible and accurate language. It distills key concepts for understanding the practice and analysis of protein crystal structures and contains examples of biologically-relevant molecules, complexes, and drug target structures.
Biomolecular Crystallography will be a valuable resource for advanced undergraduate and graduate students and practitioners in structural biology, crystallography, and structural bioinformatics.
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- Hardcover: 800 pages
- Publisher: Garland Science; 1 edition (October 20, 2009)
- Language: English
- ISBN-10: 0815340818
- ISBN-13: 978-0815340812
- Product Dimensions: 10.8 x 8.5 x 1.5 inches
- Shipping Weight: 4.1 pounds (View shipping rates and policies)
Macromolecular structure determination, which encompasses crystallographic pursuits undertaken from the mid-1930s to the present, has yielded scientific discoveries often considered to be the cornerstone upon which our understanding of the fundamentals of life can be built. As the technology and information renaissance has evolved, the spotlight has been cast upon the need for a deeper understanding of the mysteries locked within the structure of macromolecular systems and for knowledgeable and astute practitioners of diffraction science whom hold the keys to unlock those secrets. In order to properly train the next generation of structural biologists educated in crystallography, it is essential to have a modern reference volume which deftly unites the various topics critical to this field of science. Such a need has been addressed by Biomolecular Crystallography, which not only focuses on the key elements essential for any crystallographic textbook, such as crystal growth, the physics of diffraction, symmetry, the phase problem, model building, refinement and validation, but also includes information useful for the practicing structural biologist, such as protein production and engineering, bioinformatics and structure-based drug design.
As a crystallographer myself, I was especially intrigued by the organization of the volume which is reminiscent of a crystallographic structural determination. The books thirteen chapters, further arranged into five parts, cover various topics as one proceeds from a protein sequence to a crystal, the fundamentals of protein crystallography, data collection, structure determination and interpreting your structure.
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